Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.73 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.73 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | FAAH | O00519 | 2/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | PPARD | Q03181 | 1/20 | 0.54 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.54 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.54 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL29020019 | 1.00 | FFAR1 (0.73) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL28707278 | 1.00 | FFAR1 (0.73) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL28392186 | 1.00 | FFAR1 (0.73) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL672595 | 0.98 | FFAR1 (0.70) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Bicarbonate SCHEMBL2983400 | 0.93 | FFAR1 (0.76) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL27652869 | 0.92 | FFAR1 (0.63) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL1171378 | 0.92 | FFAR1 (0.63) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL8669158 | 0.90 | FFAR1 (0.59) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL31374674 | 0.90 | FFAR4 (0.79) | FFAR1FFAR4GPR84NFKB1FAAH | |
| Acetic Acid SCHEMBL31374652 | 0.90 | FFAR4 (0.79) | FFAR1FFAR4GPR84NFKB1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2557073-B1 | A method for improving spreading properties of fatty alcohol compounds, products, and uses of the same | INT FLORA TECH LTD (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-1682482-B1 | A METHOD FOR IMPROVING SPREADING PROPERTIES OF FATTY ALCOHOL COMPOUNDS, PRODUCTS, AND USES OF THE SAME | INT FLORA TECHNOLOGIES LTD (US) | 2013-03-13 | — | — | EP | disclosed |
| EP-2557073-A1 | A method for improving spreading properties of fatty alcohol compounds, products, and uses of the same | International Flora Technologies, Ltd. (US) | 2013-02-13 | — | — | EP | disclosed |
| EP-1682482-A4 | A METHOD FOR IMPROVING SPREADING PROPERTIES OF FATTY ALCOHOL COMPOUNDS, PRODUCTS, AND USES OF THE SAME | INT FLORA TECHNOLOGIES LTD (US) | 2009-07-01 | — | — | EP | disclosed |
| US-7304177-B2 | Method for improving spreading properties of cosmetic ingredients | INTERNATIONAL FLORA TECHNOLOGIES, LTD. (US) | 2007-12-04 | — | — | US | disclosed |
| EP-1682482-A1 | A METHOD FOR IMPROVING SPREADING PROPERTIES OF FATTY ALCOHOL COMPOUNDS, PRODUCTS, AND USES OF THE SAME | International Flora Technologies, Ltd. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005040090-A1 | A METHOD FOR IMPROVING SPREADING PROPERTIES OF FATTY ALCOHOL COMPOUNDS, PRODUCTS, AND USES OF THE SAME | INTERNATIONAL FLORA TECHNOLOGIES, LTD (US) | 2005-05-06 | — | — | WO | disclosed |
| US-20050079191-A1 | Method for improving spreading properties of fatty alcohol compounds, products, and uses of the same | INTERNATIONAL FLORA TECHNOLOGIES, LTD. | 2005-04-14 | — | — | US | disclosed |