Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR1F | P30939 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3620985 | 0.86 | HTR6 (0.59) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL3622517 | 0.81 | HTR6 (0.74) | HTR6CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL3620059 | 0.81 | HTR6 (0.56) | HTR6CYP3A4CYP2D6HTR1AHTR1D | |
| SCHEMBL3621867 | 0.79 | HTR6 (0.48) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL13142727 | 0.79 | HTR6 (0.48) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL3620066 | 0.77 | HTR6 (0.56) | HTR6CYP3A4CYP2D6HTR1AHTR1D | |
| Trifluoroacetic Acid SCHEMBL3624261 | 0.75 | HTR6 (0.47) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL3624262 | 0.74 | HTR6 (0.41) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL3621863 | 0.74 | HTR6 (0.50) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Trifluoroacetic Acid SCHEMBL3625968 | 0.72 | HTR6 (0.53) | HTR6CYP3A4CYP2D6HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | claimed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | claimed |
| EP-2046741-B1 | INDOLES AS 5-HT6 MODULATORS | PROXIMAGEN LTD (GB) | 2012-10-31 | — | — | EP | disclosed |
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |