Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H1 | O43463 | 2/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021891 | 0.94 | SUV39H1 (0.52) | SUV39H1PRMT1SMYD3PAK1CYP1A2 | |
| SCHEMBL4023489 | 0.89 | CYP1A2 (0.56) | SUV39H1PRMT1SMYD3PAK1CYP1A2 | |
| SCHEMBL4024379 | 0.88 | CCNE1 (0.47) | CCNE1CDK2GRM5AR | |
| SCHEMBL4024378 | 0.85 | CYP1A2 (0.57) | SUV39H1PRMT1SMYD3PAK1CYP1A2 | |
| SCHEMBL4017884 | 0.82 | PAK1 (0.63) | SUV39H1PRMT1SMYD3PAK1CYP1A2 | |
| SCHEMBL4018937 | 0.81 | ALDH1A1 (0.52) | GRM5 | |
| SCHEMBL4023998 | 0.81 | CYP1A2 (0.53) | SUV39H1PRMT1SMYD3PAK1CYP1A2 | |
| SCHEMBL4022823 | 0.81 | CYP1A2 (0.53) | SUV39H1PRMT1SMYD3PAK1CYP1A2 | |
| SCHEMBL4019432 | 0.81 | CNR1 (0.57) | SUV39H1PRMT1SMYD3PAK1CYP1A2 | |
| SCHEMBL4582908 | 0.81 | GRM5 (0.49) | PAK1CCNE1CDK2LRRK2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |