Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3463407 | 0.91 | CCR1 (0.53) | RAB9AMAPTMAPK1HTTCCR1 | |
| SCHEMBL13184089 | 0.82 | CCR1 (0.61) | RAB9AMAPTMAPK1HTTCCR1 | |
| SCHEMBL3469019 | 0.81 | CCR1 (0.50) | RAB9AMAPTMAPK1HTTCCR1 | |
| SCHEMBL3464221 | 0.81 | CCR1 (0.60) | RAB9AMAPTMAPK1HTTCCR1 | |
| SCHEMBL12765632 | 0.78 | CCR1 (0.65) | RAB9ACCR1ALK | |
| SCHEMBL1639577 | 0.76 | CCR1 (0.69) | RAB9ACCR1 | |
| SCHEMBL13162415 | 0.75 | ADRB1 (0.56) | HTTALK | |
| SCHEMBL14724221 | 0.75 | CCR1 (0.62) | RAB9ACCR1 | |
| Hydrochloric Acid SCHEMBL3465059 | 0.74 | ADRB1 (0.55) | HTTALK | |
| SCHEMBL3855803 | 0.74 | CCR1 (0.55) | RAB9AHTTCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |