Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.33 |
| ▸ | CCR1 | P32246 | 13/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | SORD | Q00796 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016957 | 0.82 | KDM4E (0.44) | ALDH1A1LMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL6170444 | 0.80 | CCR1 (0.42) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4314605 | 0.80 | HRH3 (0.47) | ALDH1A1LMNASMN1; SMN2HTR6CCR1 | |
| SCHEMBL4014891 | 0.80 | CCR1 (0.37) | LMNACCR1OGA | |
| SCHEMBL4012574 | 0.79 | OGA (0.36) | CCR1OGACYP2C19KCNH2 | |
| SCHEMBL4017114 | 0.79 | CCR1 (0.39) | CCR1OGACYP2C19KCNH2 | |
| SCHEMBL4313193 | 0.79 | CCR1 (0.46) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4019904 | 0.78 | CCR1 (0.53) | ALDH1A1LMNAMAPTCCR1CYP2C19 | |
| SCHEMBL4018625 | 0.78 | CCR1 (0.53) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4019945 | 0.78 | OGA (0.41) | CCR1OGACYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |