Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 10/20 | 0.40 |
| ▸ | KDR | P35968 | 10/20 | 0.40 |
| ▸ | KIF5B | P33176 | 8/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296984 | 0.89 | ENPP1 (0.63) | ENPP1EGFRRETKDRKIF5B | |
| SCHEMBL30054610 | 0.89 | ENPP1 (0.63) | ENPP1EGFRRETKDRKIF5B | |
| SCHEMBL12604685 | 0.83 | ENPP1 (0.52) | ENPP1EGFRRETKDRKIF5B | |
| SCHEMBL30032092 | 0.83 | ENPP1 (0.63) | ENPP1EGFRRETKDRKIF5B | |
| SCHEMBL666884 | 0.83 | ENPP1 (0.63) | ENPP1EGFRRETKDRKIF5B | |
| Hydrochloric Acid SCHEMBL28108173 | 0.81 | ENPP1 (0.61) | ENPP1EGFRRETKDRKIF5B | |
| SCHEMBL6160435 | 0.79 | ENPP1 (0.84) | ENPP1EGFRRETKDRKIF5B | |
| SCHEMBL3766549 | 0.79 | ENPP1 (0.52) | ENPP1EGFRRETKDRKIF5B | |
| SCHEMBL12604686 | 0.78 | SRC (0.39) | EGFRRETKDRKIF5BFLT1 | |
| Acetic Acid SCHEMBL3170544 | 0.77 | ENPP1 (0.56) | ENPP1EGFRRETKDRKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094211-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF TREATING CANCER | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-30 | — | — | WO | disclosed |