Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | KIF5B | P33176 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892775 | 0.89 | ENPP1 (0.65) | ENPP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4020394 | 0.83 | ENPP1 (0.51) | ENPP1KDRRETKIF5BAURKA | |
| SCHEMBL10121522 | 0.82 | ENPP1 (0.65) | ENPP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3766549 | 0.77 | ENPP1 (0.52) | ENPP1KDRRETKIF5BFLT1 | |
| SCHEMBL2607973 | 0.77 | ENPP1 (0.49) | ENPP1ALDH1A1MAPTKDRRET | |
| SCHEMBL29359187 | 0.76 | ENPP1 (0.81) | ENPP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL364049 | 0.76 | ENPP1 (0.81) | ENPP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8212200 | 0.76 | ENPP1 (0.47) | ENPP1ALDH1A1MAPTKDRRET | |
| SCHEMBL1781406 | 0.76 | ENPP1 (0.56) | ENPP1KDREGFRLCKMAPK1 | |
| Hydrochloric Acid SCHEMBL3526531 | 0.75 | ENPP1 (0.79) | ENPP1MAPTKDRAURKAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110117084-A1 | VANDETANIB DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110117084-A1 | VANDETANIB DERIVATIVES | KDR, VHL, FLT4 | ENPP1 702/4885ALDH1A1 1741/4885KMT2A 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.