Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 8/20 | 0.44 |
| ▸ | CDK2 | P24941 | 8/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.44 |
| ▸ | AURKA | O14965 | 6/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019869 | 0.89 | CCNA2 (0.41) | CCNA2CDK2CCNA1AURKAOPRK1 | |
| SCHEMBL4017921 | 0.88 | OPRK1 (0.38) | CCNA2CDK2CCNA1AURKAOPRK1 | |
| SCHEMBL2915158 | 0.86 | CCNA2 (0.46) | CCNA2CDK2CCNA1AURKAEP300 | |
| SCHEMBL2915512 | 0.85 | CCNA2 (0.46) | CCNA2CDK2CCNA1AURKAEP300 | |
| SCHEMBL2920073 | 0.85 | CCNA2 (0.46) | CCNA2CDK2CCNA1AURKAEP300 | |
| SCHEMBL2918778 | 0.84 | NPC1 (0.47) | CCNA2CDK2CCNA1AURKAEP300 | |
| SCHEMBL2920179 | 0.84 | CCNA2 (0.45) | CCNA2CDK2CCNA1AURKAPOLB | |
| SCHEMBL2913220 | 0.83 | AURKA (0.43) | CCNA2CDK2CCNA1AURKAPOLB | |
| SCHEMBL2918879 | 0.83 | MAPT (0.49) | CCNA2CDK2CCNA1AURKALMNA | |
| SCHEMBL2921266 | 0.82 | CCNA2 (0.63) | CCNA2CDK2CCNA1AURKAEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531531-B2 | Method of treating diseases associated with altered kinase activity with bicyclo-pyrazoles | PFIZER ITALIA S.R.L. (IT) | 2009-05-12 | — | — | US | disclosed |
| US-20070191386-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191386-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K20, MAP3K19, MAP3K1 | CCNA2 848/4885CDK2 43/4885CCNA1 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.