Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017912 | 0.90 | PAK1 (0.46) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4024040 | 0.86 | PAK1 (0.47) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4022683 | 0.82 | PAK1 (0.42) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4023839 | 0.81 | MEN1 (0.52) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4024051 | 0.79 | PAK1 (0.57) | PAK1KMT2AMEN1P2RX7CNR1 | |
| SCHEMBL4024845 | 0.79 | DRD2 (0.61) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4582882 | 0.79 | MAPT (0.59) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4016122 | 0.78 | PAK1 (0.51) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4583078 | 0.76 | KDR (0.56) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4019812 | 0.75 | PAK1 (0.58) | PAK1KMT2AMEN1P2RX7CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | disclosed |