Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015411 | 0.90 | DRD4 (0.53) | CCNE1CDK2DRD4HTR1ADRD2 | |
| SCHEMBL4020873 | 0.88 | PDGFRB (0.61) | PDGFRBCCNE1CDK2USP30 | |
| SCHEMBL4024845 | 0.81 | DRD2 (0.61) | DRD4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL4016402 | 0.79 | MEN1 (0.56) | DRD4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL4020829 | 0.77 | MEN1 (0.46) | CCNE1CDK2DRD4DRD2USP30 | |
| SCHEMBL4022666 | 0.77 | PAK1 (0.60) | DRD4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL4020162 | 0.75 | DRD4 (0.55) | CCNE1CDK2DRD4POLBMEN1 | |
| SCHEMBL4583078 | 0.75 | KDR (0.56) | CCNE1CDK2DRD4HTR1ADRD2 | |
| SCHEMBL4018090 | 0.74 | PDGFRB (0.60) | PDGFRBUSP30 | |
| SCHEMBL4582882 | 0.73 | MAPT (0.59) | PDGFRBCCNE1CDK2DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |