Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.77 |
| ▸ | CNR2 | P34972 | 1/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12106520 | 0.91 | PTGS2 (0.71) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL6754016 | 0.88 | PTGS2 (0.88) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL220697 | 0.87 | PTGS2 (0.78) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL29170168 | 0.87 | PTGS2 (0.86) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL5806528 | 0.87 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL217602 | 0.86 | PTGS2 (0.68) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL16010166 | 0.86 | PTGS2 (0.84) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL12742120 | 0.86 | PTGS2 (0.91) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL30077218 | 0.86 | PTGS2 (0.91) | PTGS2PTGS1CNR2AKR1C3HTR1A | |
| SCHEMBL13813542 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CNR2AKR1C3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154999-B1 | NITROXYDERIVATIVES HAVING ANTIINFLAMMATORY, ANALGESIC AND ANTITHROMBOTIC ACTIVITY | NICOX SA (FR) | 2009-04-15 | — | — | EP | disclosed |
| US-6613784-B1 | Cyclooxygenase inhibitors such as 2-acetyloxybenzoic acid 6-(nitroxymethyl)-2-methylpyridinyl ester hydrochloride, having good kinetics, solubility and efficiency; nontoxic | NICOX S.A. (FR) | 2003-09-02 | — | — | US | disclosed |
| CN-1342147-A | Nitrooxyderivatives having anti-inflammatory, analgesic and antithrombotic activity | NICOX SA (FR) | 2002-03-27 | — | — | CN | disclosed |
| EP-1154999-A1 | NITROXYDERIVATIVES HAVING ANTIINFLAMMATORY, ANALGESIC AND ANTITHROMBOTIC ACTIVITY | NICOX S.A. (FR) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000051988-A1 | NITROXYDERIVATIVES HAVING ANTIINFLAMMATORY, ANALGESIC AND ANTITHROMBOTIC ACTIVITY | NICOX S.A. (FR) | 2000-09-08 | — | — | WO | disclosed |