Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28126476 | 0.85 | RAB9A (0.52) | RAB9ANPC1MAPTGAAALDH1A1 | |
| SCHEMBL19244168 | 0.78 | APP (0.66) | ATMALDH1A1APPSMN1; SMN2CYP2C9 | |
| SCHEMBL12173625 | 0.78 | APP (0.66) | ATMALDH1A1APPSMN1; SMN2CYP2C9 | |
| SCHEMBL7815282 | 0.75 | RAB9A (0.68) | RAB9ANPC1MAPTGAAALDH1A1 | |
| SCHEMBL3012942 | 0.72 | ATM (0.47) | ATMRAB9ANPC1MAPTALDH1A1 | |
| Butyl Cinnamate SCHEMBL27987671 | 0.72 | APP (0.58) | ATMALDH1A1HCAR2APPMEN1 | |
| SCHEMBL27569796 | 0.72 | ATM (0.70) | ATMRAB9AMAPTALDH1A1HCAR2 | |
| SCHEMBL12173626 | 0.71 | APP (0.64) | ATMHCAR2APPSMN1; SMN2 | |
| SCHEMBL269917 | 0.71 | ATM (1.00) | ATMRAB9AMAPTALDH1A1HCAR2 | |
| SCHEMBL10423863 | 0.71 | ATM (1.00) | ATMRAB9AMAPTALDH1A1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339690-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |