⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31099129 | 0.84 | — | — | |
| SCHEMBL487841 | 0.74 | — | — | |
| SCHEMBL30019312 | 0.74 | — | — | |
| SCHEMBL29561566 | 0.74 | — | — | |
| SCHEMBL5654442 | 0.74 | — | — | |
| SCHEMBL23289007 | 0.74 | — | — | |
| SCHEMBL1074581 | 0.74 | — | — | |
| SCHEMBL29782947 | 0.74 | — | — | |
| SCHEMBL266594 | 0.74 | — | — | |
| SCHEMBL1344323 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117143108-B | 8-bromo-2-methylbenzofuran [2,3-b ] pyridine and synthetic method | 蒲城欧得新材料有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-117143108-A | 8-bromo-2-methylbenzofuran [2,3-b ] pyridine and synthetic method | 蒲城欧得新材料有限公司 | 2023-12-01 | — | — | CN | claimed |
| CN-116113635-B | Spiro compounds as melanocortin 4 receptor antagonists and uses thereof | 辉瑞公司 | 2025-03-18 | — | — | CN | disclosed |
| US-20250084084-A1 | Crystalline form of (2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one | PFIZER INC. (US) | 2025-03-13 | — | — | US | disclosed |
| WO-2024255412-A1 | SPIRO HETEROCYCLIC COMPOUND AND USE THEREOF | 广州必贝特医药股份有限公司 | 2024-12-19 | — | — | WO | disclosed |
| EP-4161927-B9 | SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER (US) | 2024-11-06 | — | — | EP | disclosed |
| CN-118510780-A | Spiro heterocyclic compounds and uses thereof | 广州必贝特医药股份有限公司 | 2024-08-16 | — | — | CN | disclosed |
| EP-4161927-B1 | SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER (US) | 2024-08-07 | — | — | EP | disclosed |
| CN-117143108-B | 8-bromo-2-methylbenzofuran [2,3-b ] pyridine and synthetic method | 蒲城欧得新材料有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-117143108-B | 8-bromo-2-methylbenzofuran [2,3-b ] pyridine and synthetic method | 蒲城欧得新材料有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-117143108-A | 8-bromo-2-methylbenzofuran [2,3-b ] pyridine and synthetic method | 蒲城欧得新材料有限公司 | 2023-12-01 | — | — | CN | disclosed |
| US-10221177-B2 | Inhibiting the transient receptor potential A1 ion channel | HYDRA BIOSCIENCES, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| WO-2019000238-A1 | 5-(PYRIDIN-3-YL)OXAZOLE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2019-01-03 | — | — | WO | disclosed |
| WO-2019005589-A1 | 5-(PYRIDIN-3-YL)OXAZOLE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2019-01-03 | — | — | WO | disclosed |
| US-20170275285-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | ELI LILLY AND COMPANY | 2017-09-28 | — | — | US | disclosed |
| US-20170275285-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | ELI LILLY AND COMPANY | 2017-09-28 | — | — | US | disclosed |
| EP-2049488-A2 | N'-CYANO-N-ALKYL HALIDE IMIDE AMIDE DERIVATIVES | Bayer CropScience AG (DE) | 2009-04-22 | — | — | EP | disclosed |
| EP-2004606-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | Bayer CropScience AG (DE) | 2008-12-24 | — | — | EP | disclosed |
| WO-2008009360-A2 | N'-CYANO-N-ALKYL HALIDE IMIDE AMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007115643-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2007-10-18 | — | — | WO | disclosed |