SCHEMBL4022778

SCHEMBL4022778

O=C(O)COc1cccc2c1CCC=C2CCO/N=C(/c1ccccc1)c1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 4/20 0.84
PTGDR Q13258 1/20 0.84
TBXAS1 P24557 11/20 0.61
TBXA2R P21731 11/20 0.44
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3771846 1.00 PTGIR (0.84) PTGIRPTGDRTBXAS1TBXA2RMEN1
SCHEMBL32681969 1.00 PTGIR (0.84) PTGIRPTGDRTBXAS1TBXA2RMEN1
SCHEMBL3771841 1.00 PTGIR (0.84) PTGIRPTGDRTBXAS1TBXA2RMEN1
SCHEMBL9014475 0.92 PTGIR (0.70) PTGIRPTGDRTBXAS1TBXA2RMEN1
SCHEMBL9014484 0.92 PTGIR (0.70) PTGIRPTGDRTBXAS1TBXA2RMEN1
SCHEMBL9014255 0.92 PTGIR (0.89) PTGIRPTGDRTBXAS1TBXA2RALDH1A1
SCHEMBL9014259 0.92 PTGIR (0.89) PTGIRPTGDRTBXAS1TBXA2RALDH1A1
SCHEMBL16938456 0.92 PTGIR (0.70) PTGIRPTGDRTBXAS1TBXA2RMEN1
SCHEMBL9974582 0.89 PTGIR (0.67) PTGIRPTGDRTBXAS1TBXA2RALDH1A1
SCHEMBL9014532 0.88 PTGIR (0.68) PTGIRPTGDRTBXAS1TBXA2RALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080299089-A1 ENDOGENEOUS REPAIR FACTOR PRODUCTION PROMOTERS ONO PHARMACEUTICAL CO., LTD. (JP) 2008-12-04 US claimed
US-20060069018-A1 Endogenous repair factor production promoters ONO PHARMACEUTICAL CO., LTD. (JP) 2006-03-30 US claimed
EP-1563846-A1 ENDOGENOUS REPAIR FACTOR PRODUCTION PROMOTERS ONO PHARMACEUTICAL CO., LTD. (JP) 2005-08-17 EP claimed
EP-0581187-B1 Oxime derivatives ONO PHARMACEUTICAL CO (JP) 1996-12-04 EP claimed
US-5480998-A Oxime derivative ONO PHARMACEUTICAL CO., LTD. (JP) 1996-01-02 US claimed
EP-0581187-A1 Oxime derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1994-02-02 EP claimed
EP-2913047-B1 PULMONARY DISEASE-SPECIFIC THERAPEUTIC AGENT CARDIO INCORPORATED (JP) 2019-05-08 EP disclosed
EP-2913047-B1 PULMONARY DISEASE-SPECIFIC THERAPEUTIC AGENT CARDIO INCORPORATED (JP) 2019-05-08 EP disclosed
EP-2898902-B1 ADVANCED HEART FAILURE TREATMENT MATERIAL AS MYOCARDIAL/CARDIOVASCULAR REGENERATION DEVICE UNIV OSAKA (JP) 2019-03-20 EP disclosed
US-9968716-B2 Drug-eluting stent graft ONO PHARMACEUTICAL CO., LTD. (JP) 2018-05-15 US disclosed
US-9968716-B2 Drug-eluting stent graft ONO PHARMACEUTICAL CO., LTD. (JP) 2018-05-15 US disclosed
US-9968716-B2 Drug-eluting stent graft ONO PHARMACEUTICAL CO., LTD. (JP) 2018-05-15 US disclosed
US-9597436-B2 Advanced heart failure treatment material as myocardial/cardiovascular regeneration device OSAKA UNIVERSITY (JP) 2017-03-21 US disclosed
US-20060069018-A1 Endogenous repair factor production promoters ONO PHARMACEUTICAL CO., LTD. (JP) 2006-03-30 US disclosed
US-20060018867-A1 Cosmetic composition and production thereof ICHIMARU PHARCOS CO., LTD 2006-01-26 US disclosed
EP-1604647-A1 Cosmetic composition containing polyorganosiloxane-containing epsilon-polylysine polymer, and polyhydric alcohol, and production thereof Ichimaru Pharcos Co., Ltd. (JP) 2005-12-14 EP disclosed
EP-1563846-A1 ENDOGENOUS REPAIR FACTOR PRODUCTION PROMOTERS ONO PHARMACEUTICAL CO., LTD. (JP) 2005-08-17 EP disclosed
EP-0581187-B1 Oxime derivatives ONO PHARMACEUTICAL CO (JP) 1996-12-04 EP disclosed
US-5480998-A Oxime derivative ONO PHARMACEUTICAL CO., LTD. (JP) 1996-01-02 US disclosed
EP-0581187-A1 Oxime derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1994-02-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080299089-A1 ENDOGENEOUS REPAIR FACTOR PRODUCTION PROMOTERS PTGER4, PTGIR, PTGER1 PTGIR 2/4885PTGDR 14/4885TBXAS1 30/4885
US-20060018867-A1 Cosmetic composition and production thereof CUTA, PARG, TYR PTGIR 4383/4885PTGDR 3360/4885TBXAS1 3463/4885
US-20060069018-A1 Endogenous repair factor production promoters PTGIR, PTGER4, PTGER1 PTGIR 1/4885PTGDR 12/4885TBXAS1 25/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.