SCHEMBL4022986

SCHEMBL4022986

NC(C(=O)O)[C@@H](NC(=O)Cc1ccccc1)c1cccnc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.51
CNR2 P34972 3/20 0.50
ECE1 P42892 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C9 P11712 1/20 0.48
ITGB3 P05106 3/20 0.47
ITGAV P06756 3/20 0.47
LMNA P02545 2/20 0.47
HPGD P15428 2/20 0.47
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
ADRB1 P08588 1/20 0.47
ADRB3 P13945 1/20 0.47
ALDH1A1 P00352 1/20 0.46
KMT2A Q03164 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
GRM8 O00222 1/20 0.44
GRM4 Q14833 1/20 0.44
KEAP1 Q14145 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5475428 0.87 CNR2 (0.61) CNR2CYP3A4CYP2C9HPGDALDH1A1
SCHEMBL1243478 0.86 EPHX2 (0.54) EPHX2CNR2ECE1CYP1A2CYP3A4
SCHEMBL14037327 0.77 ITGB3 (0.57) EPHX2CNR2ECE1CYP1A2CYP3A4
SCHEMBL6638460 0.77 ITGB3 (0.57) EPHX2CNR2ECE1CYP1A2CYP3A4
Ammonia Solution, Strong SCHEMBL4022994 0.76 ITGB3 (0.56) EPHX2CNR2ECE1CYP1A2CYP3A4
Ammonia Solution, Strong SCHEMBL27572931 0.76 ITGB3 (0.56) EPHX2CNR2ECE1CYP1A2CYP3A4
SCHEMBL5472631 0.74 CNR2 (0.55) CNR2CYP3A4CYP2C9HPGDALDH1A1
SCHEMBL1242417 0.73 CYP1A2 (0.56) EPHX2CYP1A2CYP3A4CYP2C9LMNA
SCHEMBL1242912 0.72 KCNA5 (0.53) EPHX2CYP1A2CYP3A4CYP2C9LMNA
SCHEMBL1243109 0.72 KCNA5 (0.51) EPHX2CNR2ECE1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1184374-B1 Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders ORTHO MCNEIL PHARM INC (US) 2009-01-28 EP disclosed
EP-1988078-A1 Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders Ortho-McNeil Pharmaceutical, Inc. (US) 2008-11-05 EP disclosed
EP-0923555-B1 CARBOXAMIDE DERIVATIVES OF PYRROLIDINE, PIPERIDINE AND HEXAHYDROAZEPINE FOR THE TREATMENT OF THROMBOSIS DISORDERS ORTHO MCNEIL PHARM INC (US) 2005-06-15 EP disclosed
EP-0923555-A1 CARBOXAMIDE DERIVATIVES OF PYRROLIDINE, PIPERIDINE AND HEXAHYDROAZEPINE FOR THE TREATMENT OF THROMBOSIS DISORDERS ORTHO PHARMACEUTICAL CORPORATION (US) 1999-06-23 EP disclosed
WO-1997041102-A1 CARBOXAMIDE DERIVATIVES OF PYRROLIDINE, PIPERIDINE AND HEXAHYDROAZEPINE FOR THE TREATMENT OF THROMBOSIS DISORDERS ORTHO PHARMACEUTICAL CORPORATION (US) 1997-11-06 WO disclosed