Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030901 | 0.91 | HPGD (0.40) | TSHRHPGDBRD4TP53CHRM2 | |
| SCHEMBL661214 | 0.89 | TSHR (0.55) | TSHRHPGDBRD4TP53CHRM2 | |
| SCHEMBL21708169 | 0.89 | TSHR (0.55) | TSHRHPGDBRD4TP53CHRM2 | |
| SCHEMBL20555169 | 0.88 | TBXAS1 (0.39) | — | |
| SCHEMBL660885 | 0.88 | TBXAS1 (0.39) | — | |
| SCHEMBL23111251 | 0.79 | CYP2C9 (0.32) | — | |
| SCHEMBL664099 | 0.78 | CYP19A1 (0.43) | TSHRHPGD | |
| SCHEMBL2328981 | 0.78 | PRMT5 (0.43) | TSHRHPGDBRD4TP53CHRM2 | |
| SCHEMBL661994 | 0.78 | CYP2A6 (0.44) | TSHRHPGDTP53 | |
| SCHEMBL2332530 | 0.78 | SRD5A1 (0.48) | TSHRHPGDTP53CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050736-A1 | Imidazole derivatives, processes for preparing them and their uses | UCB Pharma, S.A. (BE) | 2009-04-22 | — | — | EP | disclosed |
| EP-1706376-B1 | IMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA SA (BE) | 2009-03-04 | — | — | EP | disclosed |