Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chloroform. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL6508789 | 0.96 | — | — | |
| Chloroform SCHEMBL2819782 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8927142 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL7768433 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL35119 | 0.95 | — | — | |
| Chloroform SCHEMBL7542887 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8192102 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL7542885 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8927139 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8196816 | 0.95 | TSHR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101336983-B | Oldenlandia and quality control method of preparation containing oldenlandia | GUANGXI ZHUANG NATIONALITY AUTONOMOUS REGION HUAHONG PHARMACEUTICAL CO LTD | 2011-07-27 | — | — | CN | claimed |
| CN-101336983-A | Oldenlandia and quality control method of preparation containing oldenlandia | GUANGXI AUTONOMOUS REGION HUAH (CN) | 2009-01-07 | — | — | CN | claimed |
| US-9518050-B2 | Cyclohexyl and quinuclidinyl carbamate derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activity | ALMIRALL, S.A. (ES) | 2016-12-13 | — | — | US | disclosed |
| US-20150329535-A1 | NEW CYCLOHEXYL AND QUINUCLIDINYL CARBAMATE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITY | ALMIRALL, S.A. (ES) | 2015-11-19 | — | — | US | disclosed |
| CN-101336983-B | Oldenlandia and quality control method of preparation containing oldenlandia | GUANGXI ZHUANG NATIONALITY AUTONOMOUS REGION HUAHONG PHARMACEUTICAL CO LTD | 2011-07-27 | — | — | CN | disclosed |
| CN-101759639-A | Method for preparing nuciferine from lotus leaf | NANJING ZELANG MEDICAL TECH CO | 2010-06-30 | — | — | CN | disclosed |
| WO-2009086835-A1 | NOVEL CYANOGUANIDINES | TOPOTARGET A/S (DK) | 2009-07-16 | — | — | WO | disclosed |
| CN-101336983-A | Oldenlandia and quality control method of preparation containing oldenlandia | GUANGXI AUTONOMOUS REGION HUAH (CN) | 2009-01-07 | — | — | CN | disclosed |
| CN-1262282-C | Preparing method and use for Chinese medicine extractive with alpha-glucoside inhibiting activity | FUDAN ZHANGJIANG BIOLOG MEDICI (CN) | 2006-07-05 | — | — | CN | disclosed |
| CN-1471944-A | Preparing method and use for Chinese medicine extractive with alpha-glucoside inhibiting activity | 上海复旦张江生物医药股份有限公司 | 2004-02-04 | — | — | CN | disclosed |
| EP-1144404-A1 | PIPERIDINYLQUINOLINES AS PROTEIN TYROSINE KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2001-10-17 | — | — | EP | disclosed |
| US-4613619-A | Anti-arrhythmic amino-alcohols | AKZO N.V. (NL) | 1986-09-23 | — | — | US | disclosed |
| EP-0190587-A1 | Soluble quinazolino-1,4-benzodiazepin-5,13-dione derivatives, process for their preparation and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1986-08-13 | — | — | EP | disclosed |
| EP-0169392-A2 | Triazolobenzodiazepines and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-29 | — | — | EP | disclosed |
| EP-0167920-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| EP-0166356-A2 | 2-Substituted-aminomethyl-1,4-benzodiazepines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | disclosed |
| US-4559338-A | Soluble quinazolino-1,4-benzodiazepin-5,13-dione derivatives | MERCK & CO., INC. (US) | 1985-12-17 | — | — | US | disclosed |
| EP-0163237-A2 | Di- and tri-peptidal renin inhibitors | MERCK & CO. INC. (US) | 1985-12-04 | — | — | EP | disclosed |
| EP-0155721-A1 | Novel anti-arrhythmic amino-alcohols | AKZO N.V. (NL) | 1985-09-25 | — | — | EP | disclosed |
| US-4208531-A | ANTIBIOTICS | CANAS RODRIQUEZ ANTONIO (GB) | 1980-06-17 | — | — | US | disclosed |