Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241137 | 1.00 | HTR6 (0.39) | HTR6MEN1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL6817248 | 1.00 | HTR6 (0.39) | HTR6MEN1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL616084 | 1.00 | HTR6 (0.39) | HTR6MEN1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL1181468 | 0.98 | HTR6 (0.40) | HTR6MEN1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL22628194 | 0.98 | HTR6 (0.40) | HTR6MEN1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL548524 | 0.95 | HTR6 (0.39) | HTR6MEN1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL9632289 | 0.93 | KDM4E (0.38) | HTR6MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL28210606 | 0.93 | MEN1 (0.36) | HTR6MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1202752 | 0.93 | MEN1 (0.36) | HTR6MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9388849 | 0.93 | HTR6 (0.40) | HTR6MEN1KMT2ACYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082308-B1 | HETEROCYCLICALLY SUBSTITUTED AMIDES USED AS CALPAIN INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2009-04-01 | — | — | EP | claimed |
| US-7276500-B2 | Calcium channel blockers; cardiovascular disorders; antiarthritic agents | ABBOTT GMBH & CO. KG (DE) | 2007-10-02 | — | — | US | claimed |