Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.67 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.61 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.61 |
| ▸ | CDC7 | O00311 | 3/20 | 0.61 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.61 |
| ▸ | PAK4 | O96013 | 3/20 | 0.61 |
| ▸ | PRKACA | P17612 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | GSK3A | P49840 | 3/20 | 0.61 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.61 |
| ▸ | MELK | Q14680 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3807096 | 0.99 | ULK1 (0.66) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL23764834 | 0.92 | MAPK8 (0.71) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL23764833 | 0.92 | PTK2 (0.71) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL30086170 | 0.90 | PTK2 (0.72) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL17544689 | 0.90 | PTK2 (0.72) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL31174600 | 0.89 | ULK1 (0.64) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL3810996 | 0.88 | ULK1 (0.65) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL17547549 | 0.85 | PTK2 (0.72) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL28917032 | 0.85 | PTK2 (0.61) | ULK1PTK2MAPK8ALKPRKAA1 | |
| SCHEMBL19654194 | 0.85 | ULK1 (0.65) | ULK1PTK2MAPK8ALKPRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-B1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | claimed |
| EP-1597251-B1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010668-A1 | Pyrimidine compounds | TYMS, TYMP, DPYD | ULK1 2225/4885PTK2 4551/4885MAPK8 3281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.