Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27760064 | 0.82 | APLNR (0.53) | APLNRFFAR2JAK2NR1I2RAB9A | |
| SCHEMBL17765226 | 0.81 | APLNR (0.51) | APLNRFFAR2KMT2AMEN1CYP1A2 | |
| SCHEMBL29457012 | 0.79 | APLNR (0.54) | APLNRFFAR2JAK1TYK2JAK2 | |
| SCHEMBL24468398 | 0.74 | APLNR (0.47) | APLNRJAK2NR1I2HDAC6 | |
| SCHEMBL17445188 | 0.74 | APLNR (0.47) | APLNRJAK2NR1I2HDAC6 | |
| SCHEMBL16797554 | 0.74 | APLNR (0.46) | APLNRKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL1927308 | 0.73 | NR1I2 (0.48) | APLNRFFAR2JAK2CYP2C9CYP2C19 | |
| SCHEMBL1927306 | 0.73 | APLNR (0.48) | APLNRFFAR2JAK2CYP2C9NR1I2 | |
| SCHEMBL588472 | 0.73 | APLNR (0.48) | APLNRFFAR2JAK2NR1I2MAPK1 | |
| SCHEMBL12069877 | 0.73 | APLNR (0.48) | APLNRFFAR2JAK2NR1I2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095712-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | WO | disclosed |