Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.56 |
| ▸ | KDR | P35968 | 16/20 | 0.55 |
| ▸ | CSK | P41240 | 3/20 | 0.55 |
| ▸ | TEK | Q02763 | 3/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031619 | 0.91 | EGFR (0.53) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4027299 | 0.89 | SRC (0.56) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4025139 | 0.86 | SRC (0.55) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4021449 | 0.85 | SRC (0.54) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4030965 | 0.85 | SRC (0.60) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4026371 | 0.84 | SRC (0.54) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL3203209 | 0.83 | SRC (0.62) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL3193795 | 0.83 | SRC (0.62) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4030245 | 0.83 | SRC (0.54) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4021687 | 0.82 | SRC (0.52) | SRCKDRCSKTEKEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528925-B1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-04-22 | — | — | EP | disclosed |