Theobromine

Theobromine

SCHEMBL4024314

Cn1c(=O)[nH]c(=O)c2[nH]cnc21.Cn1cnc2c1c(=O)[nH]c(=O)n2C

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.75
CYP3A4 P08684 2/20 0.75
PMP22 Q01453 2/20 0.75
CHIT1 Q13231 1/20 0.52
CHIA Q9BZP6 1/20 0.52
ADORA2A P29274 7/20 0.51
PDE4A P27815 5/20 0.51
PDE4B Q07343 5/20 0.51
PDE4C Q08493 5/20 0.51
PDE4D Q08499 5/20 0.51
ADORA2B P29275 4/20 0.51
ADORA3 P0DMS8 3/20 0.51
ADORA1 P30542 3/20 0.51
BLM P54132 2/20 0.51
HPGD P15428 1/20 0.51
PDE3A Q14432 1/20 0.51
HSD17B10 Q99714 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.44
ATAD2 Q6PL18 1/20 0.44
LMNA P02545 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Theophylline Anhydrous SCHEMBL17748262 0.92 CYP3A4 (0.63) MAPK1CYP3A4PMP22CHIT1CHIA
Caffeine SCHEMBL17748263 0.89 ADORA2A (0.61) MAPK1CYP3A4PMP22CHIT1CHIA
Theophylline Anhydrous SCHEMBL1655326 0.89 MAPK1 (0.66) MAPK1CYP3A4PMP22CHIT1CHIA
Theophylline Anhydrous SCHEMBL2328875 0.87 ADORA2A (0.64) MAPK1CYP3A4PMP22CHIT1CHIA
Theobromine SCHEMBL11599459 0.87 CYP3A4 (1.00) MAPK1CYP3A4PMP22ADORA2APDE4A
Theobromine SCHEMBL3184 0.87 CYP3A4 (1.00) MAPK1CYP3A4PMP22ADORA2APDE4A
Theobromine SCHEMBL1690622 0.87 CYP3A4 (1.00) MAPK1CYP3A4PMP22ADORA2APDE4A
3-Methylxanthine SCHEMBL237146 0.87 ADORA2A (0.64) MAPK1CYP3A4PMP22ADORA2APDE4A
Caffeine SCHEMBL27666855 0.86 CYP3A4 (0.63) MAPK1CYP3A4PMP22CHIT1CHIA
Theobromine SCHEMBL4018409 0.86 CYP3A4 (0.66) MAPK1CYP3A4PMP22CHIT1CHIA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2768950-B1 N-DEMETHYASE GENES AND USES THEREOF UNIV IOWA RES FOUND (US) 2018-03-07 EP disclosed
EP-3217985-A1 COMPOUNDS FOR THE TREATMENT OF MYOTONIC DYSTROPHY Universitat de València (ES) 2017-09-20 EP disclosed
WO-2016075285-A1 COMPOUNDS FOR THE TREATMENT OF MYOTONIC DYSTROPHY UNIVERSITAT DE VALÈNCIA (ES) 2016-05-19 WO disclosed
US-20150184166-A1 CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES UNIVERSITY OF IOWA RESEARCH FOUNDATION 2015-07-02 US disclosed
EP-2861740-A1 CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES University of Iowa Research Foundation (US) 2015-04-22 EP disclosed
US-8951752-B2 N-demethyase genes and uses thereof UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2015-02-10 US disclosed
EP-2768950-A1 N-DEMETHYASE GENES AND USES THEREOF University of Iowa Research Foundation (US) 2014-08-27 EP disclosed
US-20140227729-A1 N-DEMETHYASE GENES AND USES THEREOF UNIVERSITY OF IOWA RESEARCH FOUNDATION IOWA CENTERS FOR ENTERPRISE (US) 2014-08-14 US disclosed
WO-2013187957-A1 CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2013-12-19 WO disclosed
CN-101896484-B Theobromine production process PERRIGO TRADING SHANGHAI CO LT 2013-06-12 CN disclosed
WO-2013059507-A1 N-DEMETHYASE GENES AND USES THEREOF UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2013-04-25 WO disclosed
CN-101896484-A Theobromine production process PERRIGO TRADING SHANGHAI CO LT 2010-11-24 CN disclosed
WO-2009089677-A1 THEOBROMINE PRODUCTION PROCESS PERRIGO TRADING (SHANGHAI) CO., LTD. (CN) 2009-07-23 WO disclosed