Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018442 | 0.99 | ADORA2A (0.31) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4018930 | 0.99 | ADORA2A (0.31) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4016364 | 0.99 | ADORA2A (0.31) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL4024763 | 0.98 | ADORA2A (0.31) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL17000504 | 0.91 | ADORA2A (0.33) | ADORA2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4018997 | 0.88 | BPTF (0.30) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4019931 | 0.88 | BPTF (0.30) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4019750 | 0.88 | BPTF (0.30) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL13870037 | 0.88 | ADORA2A (0.31) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2833339 | 0.83 | IDH1 (0.36) | ADORA2AKDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663241-B1 | 5-ARYLPYRIMIDINES AS ANTICANCER AGENTS | WYETH CORP (US) | 2009-05-27 | — | — | EP | disclosed |
| US-7524849-B2 | Antitumor agents to treat multiple drug resistant tumors; promoters of microtubule polymerization; etherification | WYETH HOLDINGS CORPORATION (US) | 2009-04-28 | — | — | US | disclosed |
| US-20050075357-A1 | 5-arylpyrimidines as anticancer agents | WYETH (US) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075357-A1 | 5-arylpyrimidines as anticancer agents | DPYD, ABCC1, ARF5 | ADORA2A 1489/4885KDM4E 1582/4885ALDH1A1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.