Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 11/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030824 | 0.87 | CYP17A1 (0.68) | CYP17A1CYP3A4 | |
| SCHEMBL4030366 | 0.86 | CYP17A1 (0.68) | CYP17A1CYP3A4 | |
| SCHEMBL4030837 | 0.83 | CYP17A1 (0.48) | CYP17A1CYP3A4 | |
| SCHEMBL4030338 | 0.82 | CYP17A1 (0.67) | CYP17A1CYP3A4 | |
| SCHEMBL4025340 | 0.81 | CYP17A1 (0.65) | CYP17A1CYP3A4PLK1 | |
| SCHEMBL7537438 | 0.81 | CYP17A1 (0.65) | CYP17A1CYP3A4PLK1 | |
| SCHEMBL7537443 | 0.81 | CYP17A1 (0.65) | CYP17A1CYP3A4PLK1 | |
| SCHEMBL4025212 | 0.81 | CYP17A1 (0.65) | CYP17A1CYP3A4PLK1 | |
| SCHEMBL4027111 | 0.81 | CYP17A1 (0.46) | CYP17A1CYP3A4 | |
| SCHEMBL5753882 | 0.78 | CYP3A4 (0.44) | CYP17A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222174-B1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA PHARMACEUTICAL (JP) | 2009-05-27 | — | — | EP | disclosed |
| US-6649643-B1 | Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-11-18 | — | — | US | disclosed |
| EP-1222174-A1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | Takeda Chemical Industries, Ltd. (JP) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001030762-A1 | IMIDAZOL-4-YLMETHANOLS USE AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-03 | — | — | WO | disclosed |