Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 7/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PAK3 | O75914 | 1/20 | 0.37 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024033 | 0.91 | PAK1 (0.56) | PAK1CNR1MAP3K5CNR2RPS6KB1 | |
| SCHEMBL4582674 | 0.87 | PAK1 (0.65) | PAK1CNR1MAP3K5CNR2HPGD | |
| SCHEMBL4023993 | 0.82 | PAK1 (0.46) | PAK1CNR1MAP3K5CNR2P2RX7 | |
| SCHEMBL4581785 | 0.81 | PAK1 (0.63) | PAK1CNR1CNR2KITP2RX7 | |
| SCHEMBL4024014 | 0.81 | PAK1 (0.52) | PAK1CNR1MAP3K5CNR2 | |
| SCHEMBL4022833 | 0.80 | PAK1 (0.57) | PAK1CNR1CNR2RPS6KB1KIT | |
| SCHEMBL4021914 | 0.80 | PAK1 (0.63) | PAK1CNR1HPGDKITP2RX7 | |
| SCHEMBL4581607 | 0.80 | PAK1 (0.65) | PAK1CNR1MAP3K5CNR2HPGD | |
| SCHEMBL4023766 | 0.79 | PAK1 (0.66) | PAK1CNR1MAP3K5CNR2HPGD | |
| SCHEMBL4016188 | 0.79 | PAK1 (0.59) | PAK1CNR1CNR2KITP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |