Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3807386 | 0.99 | IGF1R (0.59) | IGF1RSTAT6JAK2JAK3EGFR | |
| SCHEMBL13809950 | 0.87 | JAK2 (0.52) | IGF1RSTAT6JAK2JAK3EGFR | |
| Hydrochloric Acid SCHEMBL6179747 | 0.84 | IGF1R (0.56) | IGF1RSTAT6EGFRPTK2MAPK8 | |
| SCHEMBL4025643 | 0.79 | MAPK8 (0.68) | IGF1RJAK2JAK3PTK2BMAPK8 | |
| SCHEMBL13810320 | 0.79 | ULK1 (0.60) | IGF1REGFRPKMYT1INSRPTK2 | |
| Hydrochloric Acid SCHEMBL3812109 | 0.78 | MAPK8 (0.67) | IGF1RJAK2JAK3PTK2BMAPK8 | |
| Hydrochloric Acid SCHEMBL3811803 | 0.78 | ULK1 (0.59) | IGF1REGFRPKMYT1INSRPTK2 | |
| SCHEMBL26506636 | 0.77 | MAPK8 (0.56) | IGF1RSTAT6JAK2JAK3PTK2B | |
| SCHEMBL31174585 | 0.77 | PKMYT1 (0.69) | IGF1RSTAT6JAK2EGFRPKMYT1 | |
| SCHEMBL3811820 | 0.76 | IGF1R (0.50) | IGF1REGFRCCNKCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-B1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | claimed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010668-A1 | Pyrimidine compounds | TYMS, TYMP, DPYD | IGF1R 4340/4885STAT6 2395/4885JAK2 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.