SCHEMBL4024977

SCHEMBL4024977

Cc1cc2c(CCc3sc(-c4ccccc4C(F)(F)F)nc3C(C)C)noc2cc1NCC(=O)O

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 7/20 0.54
PPARA Q07869 7/20 0.54
PPARG P37231 6/20 0.54
PDE10A Q9Y233 1/20 0.34
USP1 O94782 2/20 0.33
WDR48 Q8TAF3 2/20 0.33
NR1H4 Q96RI1 2/20 0.33
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
TSHR P16473 1/20 0.32
CTSA P10619 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
KMO O15229 2/20 0.31
AKR1B1 P15121 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4028015 0.89 PPARG (0.54) PPARDPPARAPPARGCYP1A2CYP3A4
SCHEMBL4024973 0.87 PPARD (0.71) PPARDPPARAPPARG
SCHEMBL3393036 0.86 PPARD (0.62) PPARDPPARAPPARGNR1H4CYP3A4
SCHEMBL4026350 0.85 PPARD (0.54) PPARDPPARAPPARGNR1H4CTSA
SCHEMBL4033028 0.85 PPARG (0.54) PPARDPPARAPPARGUSP1WDR48
SCHEMBL4025440 0.83 PPARA (0.77) PPARDPPARAPPARGKMO
SCHEMBL4034567 0.83 PPARG (0.53) PPARDPPARAPPARGUSP1WDR48
SCHEMBL4801616 0.83 PPARD (0.52) PPARDPPARAPPARGNR1H4CYP1A2
SCHEMBL4030150 0.82 PPARG (0.52) PPARDPPARAPPARGUSP1WDR48
SCHEMBL4803370 0.81 PPARG (0.52) PPARDPPARAPPARGNR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190255022-A1 WOUND-HEALING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2019-08-22 US claimed
EP-3456327-A1 WOUND-HEALING AGENT Nippon Chemiphar Co., Ltd. (JP) 2019-03-20 EP claimed
US-20190255022-A1 WOUND-HEALING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2019-08-22 US disclosed
EP-3456327-A1 WOUND-HEALING AGENT Nippon Chemiphar Co., Ltd. (JP) 2019-03-20 EP disclosed
EP-1445258-B1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA NIPPON CHEMIPHAR CO (JP) 2009-06-24 EP disclosed
US-7402597-B2 Activator of peroxisome proliferator-activated receptor δ NIPPON CHEMIPHAR CO., LTD (JP) 2008-07-22 US disclosed
US-20070027196-A1 Activator of peroxisome proliferator-activated receptor delta SAKUMA SHOGO 2007-02-01 US disclosed
US-7119104-B2 Activator of peroxisome proliferator-activated receptor delta NIPPON CHEMIPHAR, CO., LTD. (JP) 2006-10-10 US disclosed
US-20050096363-A1 Activator of peroxisome proliferator-activated receptor delta NIPPON CHEMIPHAR CO., LTD. (JP) 2005-05-05 US disclosed
EP-1445258-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA NIPPON CHEMIPHAR CO., LTD. (JP) 2004-08-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190255022-A1 WOUND-HEALING AGENT PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PPARG 1/4885
US-20070027196-A1 Activator of peroxisome proliferator-activated receptor delta PPARA, PPARG, PPARD PPARD 3/4885PPARA 1/4885PPARG 2/4885
US-20050096363-A1 Activator of peroxisome proliferator-activated receptor delta PPARA, PPARG, PPARD PPARD 3/4885PPARA 1/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.