SCHEMBL4803370

SCHEMBL4803370

CCC(Sc1cc2onc(CCc3sc(-c4ccccc4C(F)(F)F)nc3C(C)C)c2cc1C)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARG P37231 11/20 0.52
PPARD Q03181 11/20 0.52
PPARA Q07869 11/20 0.52
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.30
NR1H4 Q96RI1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4803360 0.88 PPARD (0.68) PPARGPPARDPPARA
SCHEMBL4026350 0.87 PPARD (0.54) PPARGPPARDPPARANR1H4
SCHEMBL4033028 0.83 PPARG (0.54) PPARGPPARDPPARA
SCHEMBL4803451 0.82 PPARD (0.59) PPARGPPARDPPARANR1H4
SCHEMBL4025440 0.81 PPARA (0.77) PPARGPPARDPPARA
SCHEMBL3393036 0.81 PPARD (0.62) PPARGPPARDPPARANR1H4
SCHEMBL4024977 0.81 PPARD (0.54) PPARGPPARDPPARANR1H4
SCHEMBL4034567 0.81 PPARG (0.53) PPARGPPARDPPARA
SCHEMBL4028015 0.81 PPARG (0.54) PPARGPPARDPPARA
SCHEMBL4801616 0.81 PPARD (0.52) PPARGPPARDPPARANR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7402597-B2 Activator of peroxisome proliferator-activated receptor δ NIPPON CHEMIPHAR CO., LTD (JP) 2008-07-22 US disclosed
US-20070027196-A1 Activator of peroxisome proliferator-activated receptor delta SAKUMA SHOGO 2007-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070027196-A1 Activator of peroxisome proliferator-activated receptor delta PPARA, PPARG, PPARD PPARG 2/4885PPARD 3/4885PPARA 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.