Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.73 |
| ▸ | EGFR | P00533 | 15/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.73 |
| ▸ | FLT1 | P17948 | 12/20 | 0.73 |
| ▸ | FLT4 | P35916 | 12/20 | 0.73 |
| ▸ | RET | P07949 | 3/20 | 0.61 |
| ▸ | KIF5B | P33176 | 2/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.60 |
| ▸ | TEK | Q02763 | 2/20 | 0.60 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | CIT | O14578 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1782681 | 0.92 | KDR (0.75) | KDREGFRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL1783463 | 0.89 | EGFR (0.76) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL12604710 | 0.89 | KDR (0.67) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL1612820 | 0.86 | KDR (0.84) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL31319937 | 0.86 | KDR (0.84) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4171108 | 0.86 | KDR (0.62) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5424040 | 0.85 | KDR (1.00) | KDREGFRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL1783321 | 0.85 | KDR (0.60) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL1781457 | 0.83 | KDR (0.58) | KDREGFRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL1783178 | 0.82 | EGFR (0.89) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094210-A1 | VANDETANIB DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-30 | — | — | WO | disclosed |