Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR1F | P30939 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21066432 | 0.86 | GSK3B (0.41) | GSK3BMLYCDHRH3SCDDYRK1A | |
| SCHEMBL14164233 | 0.84 | HDAC6 (0.46) | HTR1AHTR1DHTR1FHTR1BMKNK1 | |
| SCHEMBL14164234 | 0.83 | HRH3 (0.42) | HRH3HTR1AHTR1DHTR1FHTR1B | |
| SCHEMBL28312769 | 0.83 | GSK3B (0.39) | GSK3BMLYCDHRH3SCD | |
| SCHEMBL628287 | 0.79 | GSK3B (0.37) | GSK3BMLYCDHRH3SCD | |
| SCHEMBL14314254 | 0.74 | ALOX15 (0.39) | MLYCD | |
| SCHEMBL628266 | 0.74 | GSK3B (0.34) | PARP1GSK3BMLYCDHRH3SCD | |
| SCHEMBL23679874 | 0.74 | SNCA (0.47) | — | |
| SCHEMBL4781839 | 0.73 | GSK3B (0.36) | GSK3BMLYCDHRH3SCD | |
| SCHEMBL12539166 | 0.73 | TDP1 (0.35) | MLYCDMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |