Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613286 | 0.88 | TDP1 (0.55) | L3MBTL1TDP1TSHRCES2CES1 | |
| SCHEMBL27484681 | 0.81 | TDP1 (0.36) | L3MBTL1TDP1SMN1; SMN2MAPK1CA1 | |
| SCHEMBL27475187 | 0.80 | TSHR (0.46) | L3MBTL1TDP1TSHRSMN1; SMN2MAPT | |
| SCHEMBL4025417 | 0.79 | TDP1 (0.49) | L3MBTL1TDP1TSHRCASP6NPC1 | |
| SCHEMBL20298737 | 0.76 | TDP1 (0.60) | L3MBTL1TDP1TSHRCES2CES1 | |
| SCHEMBL2257980 | 0.76 | TDP1 (0.64) | L3MBTL1TDP1TSHRCES2CES1 | |
| SCHEMBL3824611 | 0.76 | TDP1 (0.64) | L3MBTL1TDP1TSHRCES2CES1 | |
| SCHEMBL30527914 | 0.74 | TDP1 (0.62) | L3MBTL1TDP1TSHRCES2CES1 | |
| SCHEMBL21177973 | 0.74 | TDP1 (0.62) | L3MBTL1TDP1TSHRCES2CES1 | |
| SCHEMBL395027 | 0.74 | TDP1 (0.62) | L3MBTL1TDP1TSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102639498-A | Process for preparing 2- (1-phenylethyl) isoindolin-1-one compounds | CELGENE CORP | 2012-08-15 | — | — | CN | disclosed |
| EP-2029535-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |