Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.59 |
| ▸ | JAK2 | O60674 | 9/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025860 | 1.00 | JAK3 (0.59) | JAK3JAK2NTRK1PLK4MEN1 | |
| SCHEMBL4025063 | 0.90 | JAK3 (0.58) | JAK3JAK2NTRK1PLK4MEN1 | |
| SCHEMBL4025052 | 0.90 | JAK3 (0.58) | JAK3JAK2NTRK1PLK4MEN1 | |
| SCHEMBL4022668 | 0.88 | JAK3 (0.60) | JAK3JAK2NTRK1MEN1KMT2A | |
| SCHEMBL4022675 | 0.88 | JAK3 (0.60) | JAK3JAK2NTRK1MEN1KMT2A | |
| SCHEMBL13942371 | 0.87 | JAK3 (0.60) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL13942351 | 0.87 | JAK3 (0.60) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL4983862 | 0.85 | JAK3 (0.79) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL3946015 | 0.84 | JAK3 (0.57) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL13943168 | 0.81 | JAK3 (0.60) | JAK3JAK2NTRK1PLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |