Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 4/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.43 |
| ▸ | PRKACG | P22612 | 3/20 | 0.43 |
| ▸ | PRKACB | P22694 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.43 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024518 | 0.88 | PIM1 (0.68) | PIM1MEN1KMT2AKMOPRKACA | |
| SCHEMBL4031585 | 0.88 | PIM1 (1.00) | PIM1MEN1KMT2AKMOPRKACA | |
| SCHEMBL13909066 | 0.82 | PIM1 (0.69) | PIM1KMOPRKACAPRKACGPRKACB | |
| SCHEMBL14499905 | 0.81 | PIM1 (0.69) | PIM1KMOPRKACAGSK3BPDPK1 | |
| SCHEMBL4033705 | 0.81 | PIM1 (0.67) | PIM1CDK1CDK2KDRJAK3 | |
| SCHEMBL4027259 | 0.81 | PIM1 (0.67) | PIM1KMOCDK1GSK3BPDPK1 | |
| SCHEMBL14499939 | 0.80 | PIM1 (0.67) | PIM1MEN1KMT2AKMOPDPK1 | |
| SCHEMBL13811881 | 0.79 | PIM1 (0.65) | PIM1MEN1KMT2ACDK1CHUK | |
| SCHEMBL13811985 | 0.76 | PIM1 (0.60) | PIM1CDK1GSK3BCDK2SYK | |
| SCHEMBL474287 | 0.76 | HSP90AA1 (0.66) | PIM1MEN1KMT2AKMOPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399440-B1 | 5-(2-AMINOPYRIMIDIN-4-YL)BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20050228005-A1 | Protein kinase inhibitors and uses thereof | MOON YOUNG C | 2005-10-13 | — | — | US | disclosed |
| US-6825190-B2 | 4-(1,2- OR 2,1-BENZOXAZOL-5-YL)-2-AMINOPYRIMIDINES | VERTEX PHARMACEUTICALS INCORPORATED | 2004-11-30 | — | — | US | disclosed |
| WO-2002102800-A9 | 5-(2-AMINOPYRIMIDIN-4-YL) BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2004-05-06 | — | — | WO | disclosed |
| EP-1399440-A1 | 5-(2-AMINOPYRIMIDIN-4-YL)BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2004-03-24 | — | — | EP | disclosed |
| US-20040009996-A1 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-01-15 | — | — | US | disclosed |
| WO-2002102800-A1 | 5-(2-AMINOPYRIMIDIN-4-YL) BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009996-A1 | Protein kinase inhibitors and uses thereof | GSK3A, GSK3B, JAK3 | PIM1 425/4885MEN1 4291/4885KMT2A 2200/4885 |
| US-20050228005-A1 | Protein kinase inhibitors and uses thereof | GSK3A, JAK3, GSK3B | PIM1 536/4885MEN1 3629/4885KMT2A 2441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.