Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.67 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.56 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.56 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.41 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033705 | 0.92 | PIM1 (0.67) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL4025115 | 0.90 | PIM1 (0.60) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL13811881 | 0.90 | PIM1 (0.65) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL14499938 | 0.89 | PIM1 (0.59) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL13812005 | 0.86 | PIM1 (0.58) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL13811985 | 0.84 | PIM1 (0.60) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL13812003 | 0.81 | PIM1 (0.56) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL4027680 | 0.81 | PIM1 (0.78) | PIM1IP6K1IP6K3IP6K2CDK2 | |
| SCHEMBL4031585 | 0.81 | PIM1 (1.00) | PIM1CDK2GSK3BRAB9ANPC1 | |
| SCHEMBL1332294 | 0.80 | RAB9A (0.59) | CDK2MAP4K4CDC7ROCK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399440-B1 | 5-(2-AMINOPYRIMIDIN-4-YL)BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20050228005-A1 | Protein kinase inhibitors and uses thereof | MOON YOUNG C | 2005-10-13 | — | — | US | disclosed |
| US-6825190-B2 | 4-(1,2- OR 2,1-BENZOXAZOL-5-YL)-2-AMINOPYRIMIDINES | VERTEX PHARMACEUTICALS INCORPORATED | 2004-11-30 | — | — | US | disclosed |
| WO-2002102800-A9 | 5-(2-AMINOPYRIMIDIN-4-YL) BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2004-05-06 | — | — | WO | disclosed |
| EP-1399440-A1 | 5-(2-AMINOPYRIMIDIN-4-YL)BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2004-03-24 | — | — | EP | disclosed |
| US-20040009996-A1 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-01-15 | — | — | US | disclosed |
| WO-2002102800-A1 | 5-(2-AMINOPYRIMIDIN-4-YL) BENZISOXAZOLES AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009996-A1 | Protein kinase inhibitors and uses thereof | GSK3A, GSK3B, JAK3 | PIM1 425/4885IP6K1 278/4885IP6K3 144/4885 |
| US-20050228005-A1 | Protein kinase inhibitors and uses thereof | GSK3A, JAK3, GSK3B | PIM1 536/4885IP6K1 363/4885IP6K3 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.