Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.65 |
| ▸ | BTK | Q06187 | 7/20 | 0.45 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030596 | 0.87 | ESR1 (0.69) | ESR1BTKEGFR | |
| SCHEMBL4028868 | 0.84 | ESR1 (0.71) | ESR1BTKEGFRKCNJ6KCNJ5 | |
| SCHEMBL27548056 | 0.80 | ESR1 (0.62) | ESR1BTKEGFR | |
| SCHEMBL4027904 | 0.79 | ESR1 (1.00) | ESR1BTKEGFR | |
| SCHEMBL27573495 | 0.78 | ESR1 (0.61) | ESR1BTKEGFRALDH1A1SMN1; SMN2 | |
| SCHEMBL4028037 | 0.78 | ESR1 (0.61) | ESR1BTKEGFR | |
| SCHEMBL4028629 | 0.76 | ESR1 (0.65) | ESR1BTKEGFR | |
| SCHEMBL4028322 | 0.76 | ESR1 (0.71) | ESR1EGFR | |
| SCHEMBL4205205 | 0.75 | ESR1 (0.73) | ESR1BTKEGFR | |
| SCHEMBL27548054 | 0.74 | ESR1 (0.69) | ESR1BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | claimed |