Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.71 |
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | CMKLR1 | Q99788 | 9/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030596 | 0.89 | ESR1 (0.69) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4028632 | 0.84 | ESR1 (0.65) | ESR1BTKEGFRKCNJ6KCNJ5 | |
| SCHEMBL4027904 | 0.83 | ESR1 (1.00) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL27548056 | 0.81 | ESR1 (0.62) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4029342 | 0.81 | ESR1 (0.69) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4028629 | 0.80 | ESR1 (0.65) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4205205 | 0.79 | ESR1 (0.73) | ESR1BTKEGFR | |
| SCHEMBL27548054 | 0.78 | ESR1 (0.69) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4031188 | 0.78 | ESR1 (0.72) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4027946 | 0.78 | ESR1 (0.65) | ESR1BTKEGFRCMKLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | claimed |