Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 11/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036120 | 0.84 | SLC6A4 (0.48) | SLC6A4HRH3SLC6A2SLC6A3HTR2A | |
| SCHEMBL3947165 | 0.83 | SLC6A4 (0.68) | SLC6A4HRH3SLC6A2SLC6A3HTR2A | |
| SCHEMBL3941657 | 0.82 | HRH3 (0.48) | SLC6A4HRH3SLC6A2SLC6A3SOS1 | |
| SCHEMBL3941094 | 0.80 | SLC6A4 (0.67) | SLC6A4HRH3SLC6A2SLC6A3HTR2A | |
| SCHEMBL4014518 | 0.79 | SLC6A4 (0.47) | SLC6A4HRH3SLC6A2SLC6A3SOS1 | |
| SCHEMBL11955710 | 0.73 | MAPT (0.59) | HRH3 | |
| SCHEMBL3944352 | 0.70 | SLC6A4 (0.49) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL3950804 | 0.70 | SLC6A4 (0.63) | SLC6A4HRH3SLC6A2SLC6A3HTR2A | |
| SCHEMBL4012270 | 0.69 | SLC6A4 (0.61) | SLC6A4HRH3SLC6A2SLC6A3HTR2A | |
| SCHEMBL4164302 | 0.68 | SLC6A4 (0.41) | SLC6A4HRH3SLC6A2SLC6A3SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049473-A2 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008002820-A2 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | WO | disclosed |