Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.48 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942750 | 0.83 | SLC6A4 (0.68) | HRH3SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL4028648 | 0.82 | SLC6A4 (0.48) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL3944352 | 0.80 | SLC6A4 (0.49) | HRH3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4019960 | 0.79 | SLC6A4 (0.68) | HRH3SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL3948625 | 0.79 | SLC6A4 (0.45) | HRH3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4164296 | 0.76 | SLC6A4 (0.43) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL4013399 | 0.76 | HRH3 (0.46) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL4164302 | 0.75 | SLC6A4 (0.41) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL4164299 | 0.73 | SLC6A4 (0.46) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL3941094 | 0.69 | SLC6A4 (0.67) | HRH3SLC6A4SLC6A2SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049473-A2 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008002820-A2 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | WO | disclosed |