Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026326 | 0.86 | ALDH1A1 (0.35) | TDP1MAPTHSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL16176998 | 0.82 | TDP1 (0.46) | TDP1LMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL4083350 | 0.79 | TSHR (0.39) | TDP1LMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL26230907 | 0.79 | ALDH1A1 (0.46) | TDP1LMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL10321032 | 0.79 | ALDH1A1 (0.48) | TDP1LMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL23291740 | 0.79 | KDM4E (0.33) | MAPT | |
| SCHEMBL10254581 | 0.79 | TYMP (0.40) | TDP1MAPTALDH1A1 | |
| SCHEMBL10145320 | 0.79 | HSD17B10 (0.53) | TDP1LMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL7315346 | 0.79 | ALDH1A1 (0.53) | TDP1LMNAMAPTHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL952763 | 0.78 | HSD17B10 (0.51) | TDP1LMNAMAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-B1 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2009-07-01 | — | — | EP | disclosed |
| CN-100497302-C | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH AS (DK) | 2009-06-10 | — | — | CN | disclosed |
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | disclosed |
| CN-1678573-A | Diaryl urea derivatives and their use as chlorine channel blockers | NEUROSEARCH AS (DK) | 2005-10-05 | — | — | CN | disclosed |
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | KIT, ORAI1, CACNA1C | TDP1 4746/4885LMNA 2967/4885MAPT 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.