Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.38 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042302 | 0.83 | LPAR1 (0.47) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4033885 | 0.82 | LPAR1 (0.52) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4034676 | 0.80 | LPAR1 (0.71) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL13959871 | 0.79 | SLC1A3 (0.31) | ALOX5ALOX5APSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4034023 | 0.78 | LPAR1 (0.53) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3706068 | 0.77 | MAPT (0.52) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL2761636 | 0.76 | MAPT (0.53) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4037272 | 0.75 | MAPT (0.54) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4037667 | 0.74 | LPAR1 (0.48) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4032753 | 0.74 | TP53 (0.53) | LPAR1LPAR3LPAR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |