Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.53 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033885 | 0.85 | LPAR1 (0.52) | LPAR1LPAR3SMPD1LPAR2MAPT | |
| SCHEMBL4029162 | 0.82 | LPAR1 (0.78) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4035675 | 0.82 | MAPT (0.67) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3706068 | 0.80 | MAPT (0.52) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL2761636 | 0.79 | MAPT (0.53) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4042302 | 0.79 | LPAR1 (0.47) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4033791 | 0.78 | LPAR1 (0.52) | LPAR1LPAR3MAPTKDM4EMEN1 | |
| SCHEMBL4029416 | 0.78 | LPAR1 (0.46) | LPAR1LPAR3SMPD1LPAR2MAPT | |
| SCHEMBL4029141 | 0.78 | LPAR1 (0.62) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4037272 | 0.78 | MAPT (0.54) | LPAR1LPAR3LPAR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |