Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4033585 | 0.99 | EGFR (0.61) | EGFRERBB2KCNH2SRCKDR | |
| SCHEMBL4035838 | 0.90 | EGFR (0.58) | EGFRERBB2KCNH2SRCKDR | |
| Hydrochloric Acid SCHEMBL4031779 | 0.89 | EGFR (0.57) | EGFRERBB2KCNH2SRCKDR | |
| SCHEMBL4032237 | 0.87 | EGFR (0.75) | EGFRERBB2KCNH2SRCKDR | |
| Hydrochloric Acid SCHEMBL4033306 | 0.87 | EGFR (0.74) | EGFRERBB2KCNH2SRCKDR | |
| SCHEMBL4029414 | 0.87 | EGFR (0.54) | EGFRERBB2KCNH2SRCKDR | |
| SCHEMBL4029145 | 0.85 | EGFR (0.67) | EGFRERBB2KCNH2SRC | |
| Hydrochloric Acid SCHEMBL4036316 | 0.82 | EGFR (0.66) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4028921 | 0.82 | EGFR (0.66) | EGFRERBB2KCNH2SRC | |
| Hydrochloric Acid SCHEMBL5478352 | 0.81 | EGFR (0.65) | EGFRERBB2KCNH2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444210-B1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-02-18 | — | — | EP | disclosed |