Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036415 | 0.88 | BLM (0.42) | BLMOPRK1CYP3A4SLC22A2SLC22A1 | |
| SCHEMBL20293767 | 0.78 | MAPT (0.47) | OPRK1CYP3A4KCNH2TSHRCYP2D6 | |
| SCHEMBL4162402 | 0.76 | BLM (0.45) | BLMOPRK1CYP3A4SLC22A2SLC22A1 | |
| SCHEMBL666125 | 0.76 | BLM (0.45) | BLMOPRK1CYP3A4SLC22A2SLC22A1 | |
| SCHEMBL8283520 | 0.75 | MAPT (0.52) | BLMOPRK1CYP3A4SLC22A2SLC22A1 | |
| SCHEMBL3954412 | 0.75 | BLM (0.44) | BLMOPRK1CYP3A4SLC22A2SLC22A1 | |
| SCHEMBL21742103 | 0.74 | SMN1; SMN2 (0.44) | BLMKCNH2SMN1; SMN2L3MBTL1CYP2D6 | |
| SCHEMBL2700564 | 0.73 | TDP1 (0.42) | BLMOPRK1CYP3A4SLC22A2SLC22A1 | |
| SCHEMBL21742083 | 0.72 | CHRM2 (0.44) | BLMKCNH2ALOX15SMN1; SMN2L3MBTL1 | |
| SCHEMBL21742282 | 0.72 | CHRM2 (0.46) | BLMKCNH2TDP1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010493-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120729-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-10-25 | — | — | WO | disclosed |