Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761670 | 0.98 | LMNA (0.43) | LMNAMAPTL3MBTL1EDNRAMAOB | |
| SCHEMBL2761583 | 0.95 | EDNRA (0.48) | EDNRAMAOBABCG2ABCB1BCHE | |
| SCHEMBL2761687 | 0.89 | EDNRA (0.45) | EDNRAMAOBABCG2ABCB1BCHE | |
| SCHEMBL2761691 | 0.82 | ABCG2 (0.43) | LMNAMAPTL3MBTL1EDNRAMAOB | |
| SCHEMBL2761692 | 0.82 | ABCG2 (0.43) | LMNAMAPTL3MBTL1EDNRAMAOB | |
| SCHEMBL2762251 | 0.81 | BRD4 (0.47) | LMNAMAPTL3MBTL1EDNRAMAOB | |
| SCHEMBL2762090 | 0.80 | EGLN1 (0.47) | LMNAMAPTL3MBTL1MAOB | |
| SCHEMBL2761617 | 0.79 | EDNRA (0.54) | LMNAMAPTL3MBTL1EDNRAMAOB | |
| SCHEMBL2761700 | 0.75 | LMNA (0.43) | LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL2761626 | 0.75 | MAOB (0.57) | MAOBACHEKMT2ARAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100250-A1 | CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS | FIBROGEN, INC. (US) | 2009-08-13 | — | — | WO | disclosed |