Acetic Acid

Acetic Acid

SCHEMBL40308

CC(=O)O.CC(=O)O.O=C(O)O.[MgH2]

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR3 O14843 2/20 0.78
LCK P06239 1/20 0.78
FYN P06241 1/20 0.78
CA1 P00915 3/20 0.56
CA2 P00918 2/20 0.56
CA9 Q16790 1/20 0.56
LMNA P02545 3/20 0.50
TSHR P16473 2/20 0.46
THPO P40225 1/20 0.46
ALOX15 P16050 1/20 0.42
BLM P54132 1/20 0.42
PMP22 Q01453 1/20 0.42
ALDH1A1 P00352 5/20 0.36
TDP1 Q9NUW8 1/20 0.36
KDM4E B2RXH2 1/20 0.36
PTGS1 P23219 1/20 0.36
MMP12 P39900 1/20 0.36
CA4 P22748 1/20 0.36
SLC15A2 Q16348 1/20 0.35
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL9302852 1.00
Acetic Acid SCHEMBL28341631 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL2221524 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL4909088 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL9812633 0.94 FFAR3 (0.88) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL9340210 0.94
Acetic Acid SCHEMBL19920 0.94
Acetic Acid SCHEMBL8107424 0.94 FFAR3 (0.88) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL11439971 0.94 FFAR3 (0.88) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL28643469 0.94 FFAR3 (0.88) FFAR3LCKFYNCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230277523-A1 METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2023-09-07 US claimed
EP-3884935-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2023-06-14 EP claimed
CN-114340631-A Combination for reducing serum phosphate in a patient 阿德利克斯股份有限公司 2022-04-12 CN claimed
EP-3884935-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT Ardelyx, Inc. (US) 2021-09-29 EP claimed
EP-3492106-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2021-02-17 EP claimed
US-20200368223-A1 METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2020-11-26 US claimed
WO-2020237096-A1 COMBINATION FOR LOWERING SERUM PHOSPHATE IN A PATIENT ARDELYX, INC. (US) 2020-11-26 WO claimed
EP-3492106-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT Ardelyx, Inc. (US) 2019-06-05 EP claimed
US-10272079-B2 NHE3-binding compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2019-04-30 US claimed
EP-2983667-B1 NHE3-BINDING COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2019-03-20 EP claimed
CN-105392483-B NHE3 binding compounds and methods for inhibiting phosphate transport 阿德利克斯公司 2019-03-15 CN claimed
US-20160184387-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT CHARMOT DOMINIQUE (US) 2016-06-30 US claimed
EP-3030252-A2 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT Ardelyx, Inc. (US) 2016-06-15 EP claimed
WO-2015021358-A2 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT CHARMOT DOMINIQUE (US) 2015-02-12 WO claimed
EP-2161022-B1 Production of phosphate connectors and phosphate connectors produced according to the method KLOSTERFRAU MCM VETRIEB GMBH (DE) 2012-10-10 EP claimed
WO-2024151591-A1 MICROWAVE-ASSISTED SYNTHESIS OF POLYACRYLIC BEADS AND THE USE THEREOF TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2024-07-18 WO disclosed
WO-2024050003-A2 FLUID PURIFICATION COMPOSITIONS AND METHODS OF FLUID PURIFICATION USING THE SAME TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2024-03-07 WO disclosed
EP-2591354-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT Ardelyx, Inc. (US) 2013-05-15 EP disclosed
EP-2589964-A1 A method for determining the propensity for calcification Rheinisch-Westfälisch-Technische Hochschule Aachen (DE) 2013-05-08 EP disclosed
WO-2012006475-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2012-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160184387-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A3, SLC34A2, SLC34A1 FFAR3 1582/4885LCK 4357/4885FYN 4741/4885
US-20200368223-A1 METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A3, SLC34A2, SLC34A1 FFAR3 1747/4885LCK 3698/4885FYN 3912/4885
US-10272079-B2 NHE3-binding compounds and methods for inhibiting phosphate transport SLC34A3, SLC34A2, SLC34A1 FFAR3 1845/4885LCK 3574/4885FYN 4071/4885
US-20230277523-A1 METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A3, SLC34A2, SLC34A1 FFAR3 1747/4885LCK 3698/4885FYN 3912/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.