Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 11/20 | 0.51 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033577 | 0.93 | LPAR1 (0.53) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4034953 | 0.91 | LPAR1 (0.52) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4030949 | 0.91 | LPAR1 (0.53) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4031244 | 0.90 | LPAR1 (0.43) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4032135 | 0.89 | LPAR1 (0.49) | LPAR1LPAR3LPAR2KMT2AKDM4E | |
| SCHEMBL4033590 | 0.88 | LPAR1 (0.47) | LPAR1LPAR3LPAR2MAPTALDH1A1 | |
| SCHEMBL4034499 | 0.88 | LPAR1 (0.48) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4031276 | 0.88 | LPAR1 (0.46) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4034108 | 0.86 | LPAR1 (0.44) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4034918 | 0.86 | LPAR1 (0.45) | LPAR1LPAR3LPAR2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |