⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11111331 | 0.73 | — | — | |
| SCHEMBL3633565 | 0.69 | — | — | |
| SCHEMBL12389002 | 0.67 | — | — | |
| Acetone SCHEMBL21835119 | 0.61 | — | — | |
| Acetone SCHEMBL29657100 | 0.61 | — | — | |
| SCHEMBL9936522 | 0.59 | LMNA (0.36) | — | |
| Acetone SCHEMBL1664573 | 0.59 | — | — | |
| SCHEMBL15257797 | 0.59 | — | — | |
| SCHEMBL902574 | 0.59 | — | — | |
| Methylglyoxal SCHEMBL47032 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307454-B1 | DERIVATIVES OF VARIOLIN B | PHARMA MAR SA (ES) | 2009-06-03 | — | — | EP | disclosed |
| EP-1299388-B1 | VARIOLIN DERIVATIVES AS ANTI-CANCER AGENTS | PHARMA MAR SA (ES) | 2009-05-13 | — | — | EP | disclosed |
| US-7329666-B2 | Derivatives of variolin B | PHARMA MAR, S.A. (ES) | 2008-02-12 | — | — | US | disclosed |
| US-20080033001-A1 | Derivatives of Variolin B | UNIVERSIDAD DE BARCELONA (ES) | 2008-02-07 | — | — | US | disclosed |
| US-7320981-B2 | Antitumor agents | PHARMA MAR, S.A. (ES) | 2008-01-22 | — | — | US | disclosed |
| US-20050014778-A1 | Variolin derivatives as anti-cancer agents | PHARMA MAR, S.A. (ES) | 2005-01-20 | — | — | US | disclosed |
| US-20040058939-A1 | Derivatives of variolin b | PHARMA MAR, S.A. (ES) | 2004-03-25 | — | — | US | disclosed |
| EP-1307454-A1 | DERIVATIVES OF VARIOLIN B | Universidad de Barcelona (ES) | 2003-05-07 | — | — | EP | disclosed |
| EP-1299388-A1 | VARIOLIN DERIVATIVES AS ANTI-CANCER AGENTS | PHARMA MAR, S.A. (ES) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002012240-A1 | DERIVATIVES OF VARIOLIN B | UNIVERSIDAD DE BARCELONA (ES) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002004447-A1 | VARIOLIN DERIVATIVES AS ANTI-CANCER AGENTS | PHARMA MAR, S.A. (ES) | 2002-01-17 | — | — | WO | disclosed |
| US-5696262-A | TRIAZINE DYES FOR POLYAMIDE FIBER; PHOTOSTABILITY, HEAT AND RADIATION RESISTANCE | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| US-5578667-A | PHOTOSTABILITY, HEAT RESISTANCE | CIBA-GEIGY CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0703227-A1 | Watersoluble antioxidants, process of their preparation, and their use for the photochemical and thermical stabilisation of polyamide fibers | CIBA-GEIGY AG (CH) | 1996-03-27 | — | — | EP | disclosed |
| EP-0702011-A1 | Water soluble piperidine-triazine compounds for use as stabilizers for polyamide fibers | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |
| US-5312917-A | Polyamide fiber stabilizers | CIBA-GEIGY CORPORATION (US) | 1994-05-17 | — | — | US | disclosed |
| EP-0546993-A1 | Water soluble triazine derivatives for the photochemical and thermal stabilisation of polyamide fiber materials | CIBA-GEIGY AG (CH) | 1993-06-16 | — | — | EP | disclosed |