Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.55 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.53 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.47 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.47 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | KLK7 | P49862 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028767 | 0.85 | LPAR1 (0.60) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL4028428 | 0.85 | LPAR1 (0.61) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL4031915 | 0.84 | LPAR1 (0.54) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL4029133 | 0.81 | LPAR1 (0.73) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL16060706 | 0.80 | LPAR1 (0.70) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL20532711 | 0.80 | LPAR1 (0.70) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL16060704 | 0.80 | LPAR1 (0.70) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL4033554 | 0.80 | LPAR1 (0.68) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL4031685 | 0.80 | LPAR1 (0.59) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL6374868 | 0.79 | LPAR1 (0.60) | LPAR1LPAR3LPAR2ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |