Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032320 | 0.88 | CRHR1 (0.38) | CRHR1CCR5 | |
| SCHEMBL4038688 | 0.85 | CRHR1 (0.39) | CRHR1GABRA2GABRB2 | |
| SCHEMBL4541866 | 0.78 | PDE4B (0.38) | CRHR1GABRA2GABRB2 | |
| SCHEMBL4510528 | 0.77 | MAPT (0.39) | GABRA2GABRB2 | |
| SCHEMBL3949241 | 0.77 | KDM4E (0.41) | — | |
| SCHEMBL5187409 | 0.74 | DPP4 (0.44) | CRHR1 | |
| SCHEMBL4038685 | 0.74 | CRHR1 (0.37) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4913608 | 0.74 | DPP4 (0.43) | CRHR1 | |
| SCHEMBL3102348 | 0.71 | DPP4 (0.41) | CRHR1 | |
| SCHEMBL3114685 | 0.70 | CRHR1 (0.38) | CRHR1GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010492-A2 | AMINOMETHYL PYRIDINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007119001-A2 | AMINOMETHYL PYRIDINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-10-25 | — | — | WO | disclosed |