SCHEMBL4032336

SCHEMBL4032336

CC(C)N1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(C)C

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 7/20 0.65
PGR P06401 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24684821 0.91 AR (0.63) ARPGR
SCHEMBL26799786 0.88 AR (0.63) ARPGR
SCHEMBL4024954 0.88 AR (0.76) AR
SCHEMBL2216099 0.85 AR (0.63) ARPGR
SCHEMBL4026199 0.85 AR (0.78) ARPGR
SCHEMBL8172287 0.85 AR (0.56) ARPGR
SCHEMBL8177485 0.85 AR (0.59) ARPGR
SCHEMBL8559864 0.84 AR (0.61) ARPGR
SCHEMBL26799996 0.83 AR (0.54) AR
SCHEMBL4027208 0.82 AR (0.74) ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11826430-B2 Anti-cancer nuclear hormone receptor-targeting compounds NUVATION BIO INC. (US) 2023-11-28 US disclosed
US-20200360523-A1 ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) 2020-11-19 US disclosed
WO-2009097996-A1 USE OF SUBSTITUTED PHENYLIMIDAZOLIDINES FOR PRODUCING MEDICAMENTS FOR TREATING METABOLIC SYNDROME SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
EP-0671156-B1 Process to prepare cosmetic or pharmaceutical compositions containing liposomes AVENTIS PHARMA SA (FR) 2001-10-24 EP disclosed
US-6162444-A Cosmetic or pharmaceutical compositions HOECHST MARION ROUSSEL (FR) 2000-12-19 US disclosed
CN-1049214-C Phenylimidazolidines, process for their preparation, their use as medicaments and pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 2000-02-09 CN disclosed
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US disclosed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US disclosed
EP-0494819-B1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1996-07-10 EP disclosed
EP-0671156-A1 Cosmetic or pharmaceutical compositions containing liposomes ROUSSEL UCLAF (FR) 1995-09-13 EP disclosed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US disclosed
CN-1063102-A New phenylimidazolidines,, prepare they method, they are as the application of medicine and the pharmaceutical composition that contains them ROUSSEL UCLAF (FR) 1992-07-29 CN disclosed
EP-0494819-A1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1992-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200360523-A1 ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS NCOA1, NCOR1, NCOA3 AR 9/4885PGR 28/4885
US-11826430-B2 Anti-cancer nuclear hormone receptor-targeting compounds NCOA1, NCOR1, NCOA3 AR 9/4885PGR 28/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.